g Below are five statements regarding the cofactors of the pyruvate dehydrogenase complex. Determine whether each statement is true or false. 1. Thiamine pyrophosphate (TPP) reacts with coenzyme-A (CoA-SH) to form a hydroxyethyl-TPP intermediate in the E1 enzyme. 2. Lipoic acid contains two thiol groups that can be reduced, serving as a carrier of electrons and an acetyl group. 3. Coenzyme-A (CoA-SH) activates acetate as a thioester. 4. Flavin adenine dinucleotide (FAD) oxidizes lipoic acid. 5. Nicotinamide adenine dinucleotide (NAD ) oxidizes FADH2.